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Game Boy "S" Games
- The Sabrina Animated Series: Zapped!
- San Francisco Rush 2049
- Scooby-Doo: Classic Creep Capers
- Shadowgate Classic
- Shamus
- Shanghai Pocket
- Shaun Palmer's Pro Snowboarder
- Shrek: Fairy Tale Freakdown
- The Simpsons: Treehouse Of Horror
- Skate or Die: Bad 'n Rad
- The Smurfs Nightmare
- Snoopy Tennis
- Snoopy's Magic Show
- Space Invaders
- Space Station: Silicon Valley
- Spawn
- Speedy Gonzales: Aztec Adventure
- Spider-Man
- Spider-Man 2: The Sinister Six
- Spongebob Squarepants: Legend of the Lost Spatula
- Spy Hunter/Moon Patrol
- Spy vs. Spy
- Star Trek: The Next Generation
- Star Wars: Episode 1 - Obi-Wan's Adventures
- Star Wars: Episode 1 - Racer
- Star Wars: Yoda Stories
- Street Fighter Alpha: Warriors Dreams
- Stuart Little: The Journey Home
- Super Breakout
- Super Mario Brothers DX
- Super Mario Land 2
- Survival Kids
- Survival Kids 2
- System Info